Abstract Search

ea0011p315 | Diabetes, metabolism and cardiovascular | ECE2006

Depot specific activation of inflammatory signalling molecules JNK and NFκB in human abdominal subcutaneous and omental adipose tissue

da Silva NF , Fowler AE , Harte AL , Baker AR , Kusminski CM , Creely SJ , O’Hare P , Kumar S , McTernan PG

Central obesity is strongly associated with sub-clinical inflammation, insulin resistance (IR) and type 2 diabetes mellitus (T2DM), but the intracellular mechanisms involved in its pathogenesis remain unclear. Recent Murine studies have implicated C-jun N terminal kinase (JNK) as an important molecule linking insulin action and inflammation, therefore we investigated JNK in human abdominal adipose tissue (AT). JNK expression/activity was assessed in abdominal subcutaneous (Abd...

0 shares

ea0011p398 | Diabetes, metabolism and cardiovascular | ECE2006

The in vitro and in vivo role of diabetic status and insulin sensitisers on the novel adipocytokine, visfatin

McGee KC , da Silva NF , Baker AR , Harte AL , Creely SJ , Hill MJ , Khanolkar M , Evans M , Kumar S , McTernan PG

Visfatin, a novel adipocytokine preferentially expressed in omental (Om) adipose tissue (AT), has been shown to exert insulin-mimetic effects in mice and humans. Recent studies in Asian populations show elevated serum visfatin levels in subjects with Type 2 Diabetes Mellitus (T2DM), suggesting a potential role for visfatin in the pathogenesis of this disease. Whilst central adiposity is closely related to IR and T2DM, the role of AT in the development of these conditions remai...

0 shares

Endocrine Abstracts

Depot specific activation of inflammatory signalling molecules JNK and NFκB in human abdominal subcutaneous and omental adipose tissue

The in vitro and in vivo role of diabetic status and insulin sensitisers on the novel adipocytokine, visfatin

BiosciAbstracts